Job Description

A cover letter is required for consideration for this position and should be attached as the first page of your resume. The cover letter should address your specific interest in the position and outline skills and experience that directly relate to this position.

The lab is seeking energetic, driven, well trained, and productive scientists to join our dynamic group and make a difference in aggressive cancers through our cancer biomarker and drug development efforts, with a focus on ALK+ lung cancers. The ideal candidates will be highly motivated recent graduates who are ready to advance into a postdoctoral position and make a 2-4 year commitment. Candidates will have a PhD in Biochemistry, Molecular Biology, Cell Biology, Cancer Biology, Bioinformatics, Pharmacology, or related Biological Science. The successful candidate must be well read and organized, fluent in written and oral English, be able to analyze data and results from experiments, and be an independent thinker, but also a team player. The individuals will be responsible for leading collaborative research projects focused on translation from patient-derived organoid models to guided precision oncology. The lab has established pipelines to obtain patient-derived material directly from the operating room for various tumor types, including lung, breast, breast metastasis, locally-invasive bladder, and brain metastasis from multiple organs. These precious samples are tested with therapies and characterized in real time, delivering information on tumor vulnerability in 7-10 days. The individuals will work with experienced researchers to test and characterize patient-derived organoids with the ultimate goal of translation of pre-clinical findings to the clinic and understanding the mechanistic bases of drug sensitivity and resistance.

• Expansion, banking, and experimentation with cell lines; generation of drug-resistant cell lines with increasing exposure; generation of cell lines from mouse tumors; experiments of gene regulation to understand mechanisms.
• Maintain growth of patient-derived cells and cell lines to generate organoids for drug screening; assemble personalized drug libraries for screening; perform high-throughput and small personalized drug screening.
• Preparation of material for bulk and single-cell sequencing; utilization of kits to collect material (DNA, RNA, protein, etc.); generation of protocols to optimize single cell sequencing; spatial multi-omic studies of tumor heterogeneity.

Candidates will have a PhD in Biochemistry, Molecular Biology, Cell Biology, Cancer Biology, Bioinformatics, Pharmacology, or related Biological Science. The successful candidate must be well read and organized, fluent in written and oral English, be able to analyze data and results from experiments, and be an independent thinker, but also a team player.

• Strong publication record
• Preferred to have Ph.D. within the last 3 years

Michigan Medicine conducts background screening and pre-employment drug testing on job candidates upon acceptance of a contingent job offer and may use a third party administrator to conduct background screenings.  Background screenings are performed in compliance with the Fair Credit Report Act. Pre-employment drug testing applies to all selected candidates, including new or additional faculty and staff appointments, as well as transfers from other U-M campuses.

Michigan Medicine improves the health of patients, populations and communities through excellence in education, patient care, community service, research and technology development, and through leadership activities in Michigan, nationally and internationally.  Our mission is guided by our Strategic Principles and has three critical components; patient care, education and research that together enhance our contribution to society.

Job openings are posted for a minimum of seven calendar days.  The review and selection process may begin as early as the eighth day after posting. This opening may be removed from posting boards and filled anytime after the minimum posting period has ended.

The University of Michigan is an equal opportunity/affirmative action employer.

About University of Michigan - Ann Arbor

A great university is made so by its faculty and staff, and Michigan is recognized as one of the best universities to work for in the country. The Michigan culture is known for engaging faculty and staff in all facets of the university to create a workplace that is vibrant and stimulating.For two consecutive years, the Chronicle of Higher Education has placed U-M in its "Great Colleges to Work For" survey. In particular, the university earns high marks for strong relations between faculty and administrators, a collaborative system of governance, strong pay and benefits, and a healthy work/life balance.

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